infection with intestinal metaplasia: An independent risk factor for colorectal adenomas.

AIM

To explore the association between () infection status, intestinal metaplasia (IM), and colorectal adenomas.

METHODS

We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing, C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies.

RESULTS

The prevalence of infection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively. infection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95%CI: 1.044-1.753, = 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785, = 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95%CI: 1.216-2.277, = 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929, = 0.059). Stratification based on infection stage and IM revealed that IM accompanied by infection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95%CI: 1.383-3.216, = 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757, = 0.012).

CONCLUSION

-related IM is associated with a high risk of colorectal adenomas in Chinese individuals.