O'Hagan K P, Hora D F, Zambraski E J
Department of Biology, Rutgers University, New Brunswick, New Jersey 08903.
Am J Physiol. 1992 Oct;263(4 Pt 2):R954-61. doi: 10.1152/ajpregu.1992.263.4.R954.
Exercise-induced proteinuria may be increased in hypertensives. The mechanisms underlying the increased proteinuria are not known, and it has not been determined whether animal models of hypertension exhibit a similar response. We investigated whether indomethacin (Indo) altered exercise-induced proteinuria in normal and hypertensive deoxycorticosterone acetate (DOCA) Yucatan miniature swine (YMS). Five normal and four DOCA YMS underwent 30 min of treadmill exercise at 80% of maximal heart rate. Cumulative (exercise + recovery) albumin excretion in the DOCA YMS was 25-fold (P < 0.01) greater than observed in the normal YMS. Indo had no effect on resting or exercise-induced proteinuria in the normal YMS. However, Indo decreased the slightly elevated proteinuria at rest, and normalized the exaggerated exercise-induced proteinuria in the DOCA YMS. The antiproteinuric effect of Indo in the DOCA YMS was not associated with altered exercise, recovery blood pressure, or glomerular filtration rate. Thus hypertensive DOCA YMS exhibit an exaggerated exercise-induced proteinuria. It is suggested that eicosanoids are involved in this abnormal renal proteinuric response to exercise.
运动性蛋白尿在高血压患者中可能会增加。蛋白尿增加的潜在机制尚不清楚，并且尚未确定高血压动物模型是否表现出类似的反应。我们研究了吲哚美辛（Indo）是否会改变正常和高血压醋酸脱氧皮质酮（DOCA）尤卡坦小型猪（YMS）的运动性蛋白尿。五只正常YMS和四只DOCA YMS以最大心率的80%进行了30分钟的跑步机运动。DOCA YMS中累积（运动+恢复）白蛋白排泄量比正常YMS中观察到的高25倍（P<0.01）。Indo对正常YMS的静息或运动性蛋白尿没有影响。然而，Indo降低了DOCA YMS静息时略有升高的蛋白尿，并使DOCA YMS中过度的运动性蛋白尿恢复正常。Indo在DOCA YMS中的抗蛋白尿作用与运动、恢复血压或肾小球滤过率的改变无关。因此，高血压DOCA YMS表现出过度的运动性蛋白尿。提示类花生酸参与了这种异常的肾脏对运动的蛋白尿反应。
