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硼酸中毒:11例报告。

BORIC ACID POISONING: REPORT OF 11 CASES.

作者信息

WONG L C, HEIMBACH M D, TRUSCOTT D R, DUNCAN B D

出版信息

Can Med Assoc J. 1964 Apr 25;90(17):1018-23.

Abstract

Boric acid poisoning in 11 infants, occurring in the newborn nursery as a result of the accidental and inadvertent use of 2.5% boric acid in the preparation of the formulae, is reported. Five of the infants died. All except two exhibited the classical symptomatology of acute boric acid poisoning, namely, diarrhea, vomiting, erythema, exfoliation, desquamation of the skin, and marked central nervous system irritation. Early manifestations of poisoning were nonspecific, and one patient died before skin manifestations were noted. Peritoneal dialysis, instituted in nine cases, was found to be the most effective method of treatment. It is recommended that boric acid, which is of doubtful therapeutic value, should be completely removed from hospitals, dispensaries and pharmacopoeias.

摘要

报告了11例婴儿硼酸中毒事件,发生在新生儿保育室,原因是在配制配方奶时意外且不当使用了2.5%的硼酸。其中5名婴儿死亡。除2名婴儿外,所有婴儿均表现出急性硼酸中毒的典型症状,即腹泻、呕吐、红斑、皮肤剥脱、脱皮以及明显的中枢神经系统刺激症状。中毒的早期表现不具特异性,1例患者在出现皮肤症状之前死亡。9例患者采用了腹膜透析,发现这是最有效的治疗方法。建议将治疗价值存疑的硼酸从医院、药房和药典中彻底去除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6c5/1922689/8fc73a2b16c2/canmedaj01045-0024-a.jpg

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