Fujita A, Takahashi H, Kurata K, Honjo I
Department of Otolaryngology, Faculty of Medicine, Kyoto University, Japan.
Ann Otol Rhinol Laryngol Suppl. 1992 Oct;157:4-6. doi: 10.1177/0003489492101s1002.
Inflammatory factors appear to play an important role in the development of otitis media with effusion (OME). However, otitis media experimentally induced by endotoxin injection or secondary immunoresponse was not persistent. In order to produce refractory OME, two pathologic conditions were necessarily combined: tubal ventilatory dysfunction and suppression of the immunologic defense mechanism by immunosuppressive drugs. In the presence of these two pathologic conditions, all cases that evidenced negative middle ear pressure due to tubal dysfunction developed OME. In the control group with either tubal dysfunction or immunosuppression alone, only 1 of 20 ears developed OME. Transtubal infection due to negative middle ear pressure caused by tubal ventilatory dysfunction may be one of the most important etiologic factors in OME.
炎症因子似乎在分泌性中耳炎（OME）的发展中起重要作用。然而，通过内毒素注射或二次免疫反应实验诱导的中耳炎并不持久。为了产生难治性OME，必须结合两种病理状况：咽鼓管通气功能障碍和免疫抑制药物对免疫防御机制的抑制。在存在这两种病理状况的情况下，所有因咽鼓管功能障碍导致中耳负压的病例都发展为OME。在仅存在咽鼓管功能障碍或免疫抑制的对照组中，20只耳朵中只有1只发展为OME。由咽鼓管通气功能障碍引起的中耳负压导致的经咽鼓管感染可能是OME最重要的病因之一。
