[Experimental studies of the state of the ground substance of the aorta in white rats exposed to the combined action of manganese and lead].

Biochemical and histochemical studies are undertaken with the purpose to establish the state of the aortic wall groung substance in white rats, poisoned over a 10-day period with lead acetate (1/100 LD50) and manganese bichloride (1/100 LD50), separately and in combination. It is demonstrated that either of the metals, both separately and in combination, lead to an increase of the quantity of acid, and to a decrease of the quantity of neutral mucopolysaccharides. It is worth noting that upon combined action, a relative augmentation takes place also of hyaluronic acid in all the layers of the aortic wall. The changes observed point to quantitative and qualitative alterations in the intercellular substances of the aortic wall leading, in turn, to disturbances in its permeability.