Fialová E, Hník P
Physiol Bohemoslov. 1977;26(3):209-17.
An attempt has been made in the present report to evaluate quantitatively the sensory activity in both vagal nerves of control rats and rats with experimental lung inflammation, by employing the integration technique. We evaluated background vagal nerve activity, resting respiration and activity during inflation at constant pressures of 5 to 20 cm of water. It was found that integrated vagal respiratory activity cannot be assessed in absolute units under our experimental conditions, because of the large scatter of data. However, when the integrated values were related, for example, to resting respiration (in percentage), it was possible to compare some respiratory parameters in control, healthy rats of the Wistar strain and rats with lung inflammation. While background activity in control rats represents 75.9% of resting respiration, this parameter is significantly higher both in rats with 2-day carrageenin lung inflammation and those intoxicated with paraquat. Lung inflation at pressures 5, 10, 15, 20 cm H2O increased vagal activity linearly both in control and the two experimental groups with the degree of lung inflation. However, values in experimental animals corresponding to those of the control group were not reached until higher inflation pressures. From the functional aspect, experimental rats had characteristic tachypnoea which returns to control values after bilateral vagotomy. Since it was found that lung compliance was significantly decreased in both carrageenin and paraquat lung processes, it is being suggested that the diminished activity from lung receptors during inflation is due to mechanical properties of the lung tissue, namely lowered lung compliance.
在本报告中，我们尝试通过采用积分技术对对照大鼠和患有实验性肺部炎症的大鼠双侧迷走神经的感觉活动进行定量评估。我们评估了背景迷走神经活动、静息呼吸以及在5至20厘米水柱恒定压力下充气时的活动。结果发现，在我们的实验条件下，由于数据的大量离散，无法以绝对单位评估整合的迷走神经呼吸活动。然而，当将整合值例如与静息呼吸相关（以百分比表示）时，就有可能比较Wistar品系对照健康大鼠和患有肺部炎症的大鼠的一些呼吸参数。对照大鼠的背景活动占静息呼吸的75.9%，而在患有2天角叉菜胶性肺部炎症的大鼠和百草枯中毒的大鼠中，该参数均显著更高。在5、10、15、20厘米水柱压力下的肺充气使对照大鼠和两个实验组的迷走神经活动均随肺充气程度呈线性增加。然而，直到更高的充气压力下，实验动物的值才达到对照组的值。从功能方面来看，实验大鼠有特征性的呼吸急促，双侧迷走神经切断术后恢复到对照值。由于发现在角叉菜胶性和百草枯性肺部病变中肺顺应性均显著降低，有人提出充气期间肺感受器活动的减弱是由于肺组织的机械特性，即肺顺应性降低。
