Vízek M, Holusa R, Palecek F
Physiol Bohemoslov. 1975;24(6):559-63.
Functional and morphological examination of the lungs was performed in rats 48 hours after intratracheal injection of 0.5 mg/kg of the herbicide paraquat. Pronounced tachypnoea was observed (235+/-20 c/min), which also persisted under urethane anaesthesia (210+/-18 c/min). In control rats the mean breathing rate was 115+/-11 and 90+/-9 c/min in wake and anaesthetized rats respectively. The rate of breathing decreased to comparable values in experimental and control rats after bilateral cervical vagotomy. The functional residual lung capacity was significantly increased in experimental rats. After vagotomy also this increase of functional residual capacity became normalized. Histologically the disease was characterized by focal formation of hyaline membranes and oedema with occasional haemorrhages and signs of inflammation. The significant role fo vagal function in lung pathology is demonstrated.
在大鼠气管内注射0.5毫克/千克除草剂百草枯48小时后，对其肺部进行了功能和形态学检查。观察到明显的呼吸急促（235±20次/分钟），在氨基甲酸乙酯麻醉下也持续存在（210±18次/分钟）。在对照大鼠中，清醒和麻醉大鼠的平均呼吸频率分别为115±11次/分钟和90±9次/分钟。双侧颈迷走神经切断术后，实验大鼠和对照大鼠的呼吸频率降至相似值。实验大鼠的功能残气量显著增加。迷走神经切断术后，这种功能残气量的增加也恢复正常。组织学上，该病的特征是透明膜的局灶性形成和水肿，偶尔有出血和炎症迹象。证明了迷走神经功能在肺部病理中的重要作用。
