d'Ivernois C, Couffinhal T, Le Métayer P, Haissaguerre M, Warin J F
Service de cardiologie et médecine interne, hôpital Saint-André, Bordeaux.
Arch Mal Coeur Vaiss. 1992 Jun;85(6):899-904.
Several epidemiological studies have shown decreased cardiovascular mortality and a lower incidence of coronary artery disease in subjects with high dietary intakes of Omega-3 polyunsaturated fatty acids. It has since been shown that Omega-3 fatty acids have a number of beneficial effects in the prevention of atherosclerosis in man: reduction of blood pressure, modifications of lipoprotein metabolism, modifications of haemostasis (increased bleeding time and reduced platelet aggregation), decreased plasma fibrinogen, modifications of the metabolism of arachidonic acid and its derivatives (decreased thromboxane and leukotriene synthesis, increased prostacyclin synthesis). Therefore, Omega-3 polyunsaturated fatty acids have several beneficial effects on the presumed mechanisms of atherogenesis and/or its complications: they could represent an original and seductive solution to the problem of prevention of cardiovascular disease.
多项流行病学研究表明，膳食中摄入大量欧米伽-3多不饱和脂肪酸的人群心血管死亡率降低，冠状动脉疾病发病率也较低。此后有研究表明，欧米伽-3脂肪酸在预防人类动脉粥样硬化方面具有多种有益作用：降低血压、改变脂蛋白代谢、改变止血功能（延长出血时间并减少血小板聚集）、降低血浆纤维蛋白原、改变花生四烯酸及其衍生物的代谢（减少血栓素和白三烯合成，增加前列环素合成）。因此，欧米伽-3多不饱和脂肪酸对动脉粥样硬化的假定发病机制和/或其并发症具有多种有益作用：它们可能是预防心血管疾病问题的一种新颖且诱人的解决方案。
