Lynch P, Bakal D, Whitelaw W, Fung T, Rose L
Division of Psychology, Foothills Hospital, Calgary, Alberta, Canada.
Behav Res Ther. 1992 Nov;30(6):591-6. doi: 10.1016/0005-7967(92)90004-z.
This study examined the importance of agoraphobic avoidance and frequency of panic as predictors of psychological and physiological responses of panic sufferers to a laboratory based provocation procedure. Psychophysiologic comparisons were made between 22 panic disorder patients and 15 controls, at baseline and across three periods of carbon dioxide gas inhalations (1, 3, 5%; balance oxygen). Subjective measures of anxiety, frightening cognitions and body sensations were obtained across the phases. Physiological measures of minute ventilation, breathing rate, tidal volume, end tidal CO2 and heart rate were also obtained. Between group comparisons revealed significant differences between the groups on the subjective measures with no significant differences occurring on the physiological measures. Within group analyses revealed that pre-session questionnaire measures of agoraphobia avoidance and panic frequency predicted the degree of anxiety, frightening sensations and cognitions during baseline and 5% CO2 inhalation. The results indicated that both self-reported agoraphobic avoidance and panic frequency are strong clinical predictors of psychological reactions of panic sufferers during laboratory provocation.
本研究检验了场所恐惧回避和惊恐发作频率作为惊恐障碍患者对基于实验室的激发程序的心理和生理反应预测指标的重要性。在基线以及三个吸入二氧化碳气体阶段（1%、3%、5%；其余为氧气），对22名惊恐障碍患者和15名对照者进行了心理生理学比较。在各个阶段获取了焦虑、恐惧认知和身体感觉的主观测量数据。还获取了分钟通气量、呼吸频率、潮气量、呼气末二氧化碳分压和心率的生理测量数据。组间比较显示，两组在主观测量指标上存在显著差异，而在生理测量指标上无显著差异。组内分析表明，会前关于场所恐惧回避和惊恐发作频率的问卷调查指标可预测基线期和吸入5%二氧化碳时的焦虑程度、恐惧感觉和认知。结果表明，自我报告的场所恐惧回避和惊恐发作频率都是惊恐障碍患者在实验室激发期间心理反应的有力临床预测指标。
