Contractor S, Hiatt M, Kosmin M, Kim H C
Department of Medicine and Pediatrics, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.
Am J Perinatol. 1992 Sep-Nov;9(5-6):409-10. doi: 10.1055/s-2007-999276.
The anticardiolipin antibody is associated with increased risk of thrombosis, which is manifested with various clinical presentations, including vascular thrombosis, recurrent fetal wastage, and neurologic defects. We report a case of neonatal thrombosis occurring in the renal vein and inferior vena cava associated with moderate positive anticardiolipin antibody titer in the baby while the maternal serum showed even stronger anticardiolipin antibody of immunoglobulin G class. Subsequent follow-up over the 4 months postpartum period showed a disappearance of the antibody in the baby, whereas the mother's antibody persisted. This case illustrates the fact that the maternal anticardiolipin antibody can be transferred to the fetus and may be a risk factor for thrombosis in the neonates. Anticardiolipin antibody syndrome should be considered in the differential diagnosis of neonatal thrombosis.
抗心磷脂抗体与血栓形成风险增加相关，其临床表现多样，包括血管血栓形成、反复流产及神经缺陷。我们报告一例新生儿肾静脉和下腔静脉血栓形成病例，患儿抗心磷脂抗体滴度呈中度阳性，而母亲血清中免疫球蛋白G类抗心磷脂抗体更强。产后4个月的后续随访显示，患儿体内抗体消失，而母亲的抗体依然存在。该病例表明，母亲的抗心磷脂抗体可转移至胎儿，可能是新生儿血栓形成的危险因素。在新生儿血栓形成的鉴别诊断中应考虑抗心磷脂抗体综合征。
