Amato M, Hüppi P, Isenschmid M, Schneider H
Department of Obstetrics and Gynecology, University of Berne, Switzerland.
Am J Perinatol. 1992 Sep-Nov;9(5-6):431-4. doi: 10.1055/s-2007-999282.
Caffeine is commonly used in the treatment of apnea of prematurity. The skin of preterm infants varies considerably in its level of maturity. To understand skin absorption in low birthweight infants (less than 1500 gm) with gestational age between 26 and 34 weeks, a group of 56 preterm babies was studied after percutaneous application of 7.5 mg twice daily of caffeine for babies with birthweight less than 1000 gm and 10 mg twice daily for babies with birthweight more than 1000 gm. The reported technique is a useful alternative method of drug administration in premature babies. This study indicates an inverse relationship between gestational age and skin absorption contributing to a better understanding of skin barrier function in the newborn.
咖啡因常用于治疗早产儿呼吸暂停。早产儿的皮肤成熟度差异很大。为了解胎龄在26至34周之间、出生体重低于1500克的低体重婴儿的皮肤吸收情况，对一组56名早产儿进行了研究，出生体重低于1000克的婴儿每日两次经皮给予7.5毫克咖啡因，出生体重超过1000克的婴儿每日两次给予10毫克咖啡因。所报道的技术是给早产儿用药的一种有用的替代方法。这项研究表明胎龄与皮肤吸收之间存在反比关系，有助于更好地理解新生儿的皮肤屏障功能。
