Cattarossi Luigi, Violino Marco, Macagno Franco, Logreco Paolo, Savoia Marilena
Department of Pediatrics, Ospedale Civile di Tolmezzo, Italy.
J Perinat Med. 2006;34(4):344-6. doi: 10.1515/JPM.2006.067.
We hypothesize that urine levels might be reliable to assess the therapeutic range of caffeine.
We correlated plasma and urinary levels of caffeine in preterm infants treated with this drug for apnea of prematurity.
Infants (n=56) were given a loading dose of caffeine citrate (10 mg/kg, per os) and 24 h later a maintenance dose (2 mg/kg, per os, once a day). Plasma and urinary levels of caffeine were determined 24 h after the loading dose (before administration of the maintenance dose) and then weekly.
Plasma and urinary levels correlate at all examined ages: 29 weeks (r=0.92, P<0.001), 30 weeks (r=0.97, P<0.001), 31 weeks (r=0.82, P<0.001), 32 weeks (r=0.92, P<0.001), 33 weeks (r=0.87, P<0.001), 34 weeks (r=0.81, P<0.001).
Urinary levels of caffeine might be a useful means to assess therapeutic ranges.
我们假设尿液水平可能是评估咖啡因治疗范围的可靠指标。
我们对接受该药治疗早产呼吸暂停的早产儿的血浆和尿液中的咖啡因水平进行了相关性研究。
婴儿（n = 56）给予枸橼酸咖啡因负荷剂量（10mg/kg，口服），24小时后给予维持剂量（2mg/kg，口服，每日一次）。在负荷剂量后24小时（给予维持剂量前）以及之后每周测定血浆和尿液中的咖啡因水平。
在所有检查的年龄阶段，血浆和尿液水平均具有相关性：29周（r = 0.92，P < 0.001），30周（r = 0.97，P < 0.001），31周（r = 0.82，P < 0.001），32周（r = 0.92，P < 0.001），33周（r = 0.87，P < 0.001），34周（r = 0.81，P < 0.001）。
尿液中的咖啡因水平可能是评估治疗范围的有用手段。
