Morisot C, Simoens C, Trublin F, Lhermitte M, Gremillet C, Robert M H, Lequien P
Service de Néonatologie, Hôpital Calmette, Centre Hospitalier Universitaire, Lille.
Arch Fr Pediatr. 1990 Mar;47(3):221-4.
In 18 prematures (gestational age less than 32 weeks), an aqueous monohydrated caffeine colloidal gel was administered topically. High plasma levels were rapidly obtained with a loading dose divided in 4 applications by massaging, 1 ml of gel per kg body weight, at 12 hour intervals (18 mg caffeine base/kg). Maintenance was then instituted with a dose of 0.5 ml/kg/day. Treatment was initiated before 8 days of life, in children under assisted ventilation but without severe pulmonary involvement, during the period of weaning from the respirator. A good local and general tolerance was invariably observed and remarkable therapeutic efficacy was obtained.
对18例早产儿（胎龄小于32周）局部应用一水合咖啡因胶体凝胶。通过按摩分4次给予负荷剂量（每千克体重1毫升凝胶，含咖啡因碱18毫克/千克），每隔12小时给药一次，迅速获得了高血浆水平。然后以0.5毫升/千克/天的剂量维持治疗。治疗在出生8天前开始，用于辅助通气但无严重肺部受累、正在脱离呼吸机的儿童。始终观察到良好的局部和全身耐受性，并获得了显著的治疗效果。
