系统性硬化症（硬皮病）中针对分枝杆菌65 kDa热休克蛋白的抗体。
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).
作者信息
Danieli M G, Candela M, Ricciatti A M, Reginelli R, Danieli G, Cohen I R, Gabrielli A
机构信息
Istituto di Clinica Medica dell'Università di Ancona, Italy.
出版信息
J Autoimmun. 1992 Aug;5(4):443-52. doi: 10.1016/0896-8411(92)90004-a.
It has been reported that immunity to the 65 kDa heat shock protein of Mycobacterium tuberculosis (MT-hsp65) not only accompanies rheumatoid arthritis (RA), but may also be characteristic of chronic inflammation. We now report serum antibodies to MT-hsp65 in 47% of systemic sclerosis (SSc), 38% of primary Raynaud's phenomenon (PRP) and 5% of systemic lupus erythematosus (SLE). Antibody levels were higher in patients with active or progressive SSc and correlated with the degree of skin fibrosis. Thus, immunity to MT-hsp65 appears in SSc and is not limited to RA. However, it does show some degree of specificity beyond chronic inflammation: PRP patients have a higher reactivity than do SLE patients.
据报道，对结核分枝杆菌65kDa热休克蛋白（MT-hsp65）的免疫不仅伴随类风湿性关节炎（RA），还可能是慢性炎症的特征。我们现在报告，47%的系统性硬化症（SSc）、38%的原发性雷诺现象（PRP）和5%的系统性红斑狼疮（SLE）患者血清中存在抗MT-hsp65抗体。活动性或进行性SSc患者的抗体水平更高，且与皮肤纤维化程度相关。因此，对MT-hsp65的免疫出现在SSc中，并不局限于RA。然而，它确实表现出一定程度的超越慢性炎症的特异性：PRP患者的反应性高于SLE患者。
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