类风湿性关节炎与抗分枝杆菌热休克蛋白65抗体水平升高无关：来自疾病不一致双胞胎对研究的结果
Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: results from a study of disease discordant twin pairs.
作者信息
Worthington J, Rigby A S, MacGregor A J, Silman A J, Carthy D, Ollier W E
机构信息
ARC Epidemiology Research Unit, University of Manchester, United Kingdom.
出版信息
Ann Rheum Dis. 1993 Jul;52(7):542-4. doi: 10.1136/ard.52.7.542.
Abstract
OBJECTIVES
To investigate the role of humoral immunity to mycobacterial hsp65 in the aetiology of rheumatoid arthritis.
METHODS
Levels of IgG antibodies to recombinant mycobacterial hsp65 were measured by enzyme linked immunosorbent assay (ELISA) in serum samples of 152 twin pairs discordant for RA and in serum samples from 62 normal blood donors.
RESULTS
No significant differences between antibody levels in the subjects with RA compared either with their unaffected twins or with a group of normal blood donors was observed. In the monozygotic twins there was a strong but negative association between levels of antibody to hsp65 and disease status. Zygosity, sex, and HLA status did not significantly affect levels of antibody to hsp65.
CONCLUSION
Previous reports of an association between hsp65 and RA were not confirmed.
摘要
目的
研究针对分枝杆菌热休克蛋白65（hsp65）的体液免疫在类风湿性关节炎病因学中的作用。
方法
采用酶联免疫吸附测定法（ELISA）检测152对患类风湿性关节炎不一致的双胞胎血清样本以及62名正常献血者血清样本中针对重组分枝杆菌hsp65的IgG抗体水平。
结果
与未患类风湿性关节炎的双胞胎或正常献血者组相比，类风湿性关节炎患者的抗体水平无显著差异。在同卵双胞胎中，hsp65抗体水平与疾病状态之间存在强烈但呈负相关的联系。合子性、性别和人类白细胞抗原（HLA）状态对hsp65抗体水平无显著影响。
结论
先前关于hsp65与类风湿性关节炎之间存在关联的报道未得到证实。
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