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The mechansim of action of coenzyme B12. The role thioester in a nonenzyme model reaction for coenzyme B12 Dependent isomerization of methylmalony coenzyme A to succinyl coenzyme A.

作者信息

Scott A I, Kang K

出版信息

J Am Chem Soc. 1977 Mar 16;99(6):1997-9. doi: 10.1021/ja00448a063.

DOI:10.1021/ja00448a063
PMID:14184
Abstract
摘要

相似文献

1
The mechansim of action of coenzyme B12. The role thioester in a nonenzyme model reaction for coenzyme B12 Dependent isomerization of methylmalony coenzyme A to succinyl coenzyme A.辅酶B12的作用机制。硫酯在辅酶B12依赖的甲基丙二酰辅酶A异构化为琥珀酰辅酶A的非酶模型反应中的作用。
J Am Chem Soc. 1977 Mar 16;99(6):1997-9. doi: 10.1021/ja00448a063.
2
Letter: A nonenzymic model intermediate for the coenzyme B 12 dependent isomerization of methymalonyl coenzyme A to succinyl coenzyme A.信函:一种非酶模型中间体,用于辅酶B12依赖的甲基丙二酰辅酶A异构化为琥珀酰辅酶A的过程。
J Am Chem Soc. 1976 Jun 9;98(12):3424-5. doi: 10.1021/ja00428a065.
3
On the mechanism of action of methylmalonyl-CoA mutase. Change of the steric course on isotope substitution.关于甲基丙二酰辅酶A变位酶的作用机制。同位素取代对空间进程的影响。
Eur J Biochem. 1986 May 2;156(3):545-54. doi: 10.1111/j.1432-1033.1986.tb09614.x.
4
The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase.
Org Biomol Chem. 2003 Sep 21;1(18):3154-9. doi: 10.1039/b305782h.
5
The putative coenzyme B12-dependent methylmalonyl-CoA mutase from potatoes is a phosphatase.来自土豆的假定的依赖辅酶B12的甲基丙二酰辅酶A变位酶是一种磷酸酶。
Bioorg Chem. 2008 Dec;36(6):261-4. doi: 10.1016/j.bioorg.2008.06.002. Epub 2008 Jul 29.
6
Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus.红霉素合成中甲基丙二酰辅酶A的来源:来自红色链霉菌的甲基丙二酰辅酶A变位酶。
Antimicrob Agents Chemother. 1984 Feb;25(2):173-8. doi: 10.1128/AAC.25.2.173.
7
[Omega-(adenosin-5'-O-yl)alkyl]cobalamins mimicking the posthomolysis intermediate of coenzyme B12-dependent rearrangements: kinetic investigations on methylmalonyl-CoA mutase.模拟辅酶B12依赖性重排反应后均裂中间体的[ω-(腺苷-5'-O-基)烷基]钴胺素:甲基丙二酰辅酶A变位酶的动力学研究
Arch Biochem Biophys. 1995 Jan 10;316(1):541-6. doi: 10.1006/abbi.1995.1072.
8
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.辅酶B12自由基是如何产生的:分辨率为2埃的甲基丙二酰辅酶A变位酶的晶体结构
Structure. 1996 Mar 15;4(3):339-50. doi: 10.1016/s0969-2126(96)00037-8.
9
Nonenzymatic model reaction for the coenzyme B12-catalyzed rearrangement of methylmalonyl-CoA into succinyl-CoA.辅酶B12催化甲基丙二酰辅酶A重排为琥珀酰辅酶A的非酶模型反应。
Angew Chem Int Ed Engl. 1975 Dec;14(12):822-3. doi: 10.1002/anie.197508221.
10
The error in the cryptic stereospecificity of methylmalonyl-CoA mutase. The use of carba-(dethia)-coenzyme A substrate analogues gives new insight into the enzyme mechanism.甲基丙二酰辅酶A变位酶神秘立体特异性中的错误。碳硼烷(脱硫)辅酶A底物类似物的使用为酶作用机制提供了新的见解。
Eur J Biochem. 1988 Apr 5;173(1):191-201. doi: 10.1111/j.1432-1033.1988.tb13984.x.

引用本文的文献

1
Photoredox mediated nickel catalyzed C(sp)-H thiocarbonylation of ethers.光氧化还原介导的镍催化醚的C(sp)-H硫羰基化反应
Chem Sci. 2017 Sep 1;8(9):6613-6618. doi: 10.1039/c7sc02516e. Epub 2017 Jul 24.
2
Vitamin B12S-promoted model rearrangement of methylmalonate to succinate is not a free radical reaction.维生素B12S促进的丙二酸单酰辅酶A向琥珀酸的模型重排不是自由基反应。
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3174-6. doi: 10.1073/pnas.87.8.3174.