Quesney L F, Constain M, Rasmussen T, Olivier A, Palmini A
Montreal Neurological Institute and Hospital, McGill University, Que., Canada.
Epilepsy Res Suppl. 1992;5:55-69.
Poor localization of the interictal epileptic abnormality and the rather unreliable EEG localization of ictal onsets in patients with frontal lobe epilepsy may be due to some of the following factors: (1) high risk of EEG sampling error, (2) early seizure spread within and outside the frontal lobe, (3) widespread distribution of the epileptogenic brain tissue responsible for the patient's habitual seizures, and (4) secondary bilateral synchrony and secondary epileptogenesis. The relevance of these factors in the preoperative investigation of patients with frontal lobe epilepsy was studied in: (a) 34 adult patients (mean age: 25 years) who became and persisted seizure free after restrictive surgical removal of the anterofrontal region, the parasagittal region convexity or the fronto-opercular area; (b) 12 patients in whom the pre-operative EEG investigation with extracranial electrodes failed to localize the site of seizure onset, leading to further investigation with depth electrodes.
额叶癫痫患者发作间期癫痫异常定位不佳以及发作期起始的脑电图定位相当不可靠，可能是由于以下一些因素：(1)脑电图采样误差风险高；(2)癫痫发作早期在额叶内外扩散；(3)导致患者习惯性发作的致痫脑组织广泛分布；(4)继发性双侧同步化和继发性癫痫发生。在以下研究中探讨了这些因素在额叶癫痫患者术前检查中的相关性：(a) 34例成年患者（平均年龄：25岁），在限制性手术切除额前区、矢状旁区凸面或额眶区后癫痫发作停止且未再发作；(b) 12例患者，术前使用头皮电极进行脑电图检查未能定位癫痫发作起始部位，因此进一步采用深部电极进行检查。
