Abrossimow W N
Allerg Immunol (Leipz). 1976;22(4):345-7.
An attempt has been made to compare the effects produced by adrenergic agents on smooth bronchial muscles of normal and BCG- as well as ovalbumin-sensitized guinea pigs. The method of determining the state of relaxation of the isolated bronchial tree was used to ascertain the degree of sensitivity to adrenergic agents of smooth bronchial muscles. Experiments conducted on a total of 34 guinea pigs showed a considerable decrease in the response of smooth bronchial muscles to novodrine, adrenaline, and noradrenaline subsequent to BCG and ovalbumin sensitization of experimental animals. In normal guinea pigs, minimal relaxation of smooth tracheal muscles was brought about by 7.10(-8) - 1.10(-7) G/ml novodrine, 1.10(-7) - 9.10(-7) g/ml adrenaline, and 1.10(-6) - 8.10(-6) g/ml noradrenaline. For BCG-sensitized animals, the data obtained were 3.10(-7) - these agents of smooth bronchial muscles of guinea pigs was more clearly evident in BCG-sensitized 2.10(-6) g/ml, 1.10(-6) - 2.10(-6) g/ml, and 3.10(-6) - 6.10(-6) g/ml, respectively. The decrease in sensitivity to bronchi during the process of sensitization is believed to be responsible for the decrease in response to animals than in ovalbumin-sensitized guinea pigs. A partial blockade of beta-adrenergic receptors of catecholamines. The degree of partial blockade is dependent upon the kind of sensitization.
人们尝试比较了肾上腺素能药物对正常豚鼠、卡介苗致敏豚鼠以及卵清蛋白致敏豚鼠支气管平滑肌的作用。采用测定离体支气管树舒张状态的方法来确定支气管平滑肌对肾上腺素能药物的敏感程度。对总共34只豚鼠进行的实验表明，在对实验动物进行卡介苗和卵清蛋白致敏后，支气管平滑肌对奴佛卡因、肾上腺素和去甲肾上腺素的反应显著降低。在正常豚鼠中，7.10(-8)-1.10(-7)G/ml的奴佛卡因、1.10(-7)-9.10(-7)g/ml的肾上腺素和1.10(-6)-8.10(-6)g/ml的去甲肾上腺素可引起气管平滑肌最小程度的舒张。对于卡介苗致敏的动物，所获得的数据分别为3.10(-7)-2.10(-6)g/ml、1.10(-6)-2.10(-6)g/ml和3.10(-6)-6.10(-6)g/ml。致敏过程中对支气管敏感性的降低被认为是导致对这些药物反应降低的原因，在卡介苗致敏的豚鼠中比在卵清蛋白致敏的豚鼠中更为明显。这是儿茶酚胺对β-肾上腺素能受体的部分阻断。部分阻断的程度取决于致敏的类型。
