Johnson S K, Medina D, Wagner G C
Department of Psychology, Rutgers University, New Brunswick, NJ.
J Neural Transm Gen Sect. 1992;89(1-2):123-7. doi: 10.1007/BF01245358.
The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72-82%) and long-lasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.
在小鼠中研究了司来吉兰对甲基苯丙胺诱导的多巴胺耗竭的影响。每隔两小时皮下注射4次12.5mg/kg的甲基苯丙胺，可导致纹状体多巴胺大量（72 - 82%）且持久的耗竭。用25mg/kg或40mg/kg的司来吉兰预处理并未显著改变这种耗竭的程度。这些结果表明，与1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）处理后观察到的情况不同，在帕金森病的甲基苯丙胺模型中，司来吉兰预处理对多巴胺能细胞没有保护作用。
