Wagner G C, Tekirian T L, Cheo C T
Department of Psychology, Rutgers University, New Brunswick, NJ.
J Neural Transm Gen Sect. 1993;93(1):67-70. doi: 10.1007/BF01244939.
Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.
雄性和雌性小鼠接受了甲基苯丙胺治疗（每次注射10.0毫克/千克，共注射四次），并在两周后处死。观察到甲基苯丙胺治疗导致纹状体多巴胺耗竭，其中雄性小鼠（74%）的耗竭程度明显高于雌性小鼠（56%）。这些结果表明，雌激素可能对甲基苯丙胺诱导的多巴胺耗竭具有保护作用，这可能与男性比女性更容易患帕金森病这一事实有关。
