细胞间黏附连接中钙黏着蛋白与肌动蛋白丝之间的分子连接
Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions.
作者信息
Tsukita S, Tsukita S, Nagafuchi A, Yonemura S
机构信息
Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan.
出版信息
Curr Opin Cell Biol. 1992 Oct;4(5):834-9. doi: 10.1016/0955-0674(92)90108-o.
The cell-cell adherens junction is a site for cadherin-mediated cell adhesion where actin filaments are densely associated with the plasma membrane through its well-developed plasmalemmal undercoat. Recent research has focused on the molecular linkage between cadherins and actin filaments in the undercoat of adherens junctions in order to understand the functions of these undercoat-constitutive proteins in the regulation and signal transduction of cadherin-based cell adhesion.
细胞间黏附连接是钙黏蛋白介导的细胞黏附位点，在此处肌动蛋白丝通过其发育良好的质膜下垫与质膜紧密相连。最近的研究集中在黏附连接下垫中钙黏蛋白与肌动蛋白丝之间的分子联系，以便了解这些构成下垫的蛋白质在基于钙黏蛋白的细胞黏附的调节和信号转导中的功能。
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