Johnsson A, Brun E, Akerman M, Cavallin-Ståhl E
Department of Oncology, University Hospital, Lund, Sweden.
Acta Oncol. 1992;31(5):525-31. doi: 10.3109/02841869209088301.
Prognostic factors and treatment results were analysed in 72 consecutive patients with primary gastric lymphoma treated between 1970 and 1985. There were 37 patients in stage IE, 17 in IIE, 3 in IIES and 15 in stage IV. Histopathological re-evaluation and classification according to the TNM system were performed. We found that disseminated disease (stage IV), serosal penetration (T3), involvement of adjacent organs (T4) and extensive abdominal lymph node involvement (N3) were poor prognostic factors. Neither histological malignancy grading, nor the appearance of lympho-epithelial lesions were significantly associated with relapse-free survival. Forty-six patients with 'limited localized' disease (stage IE, IIE, N3 excluded) received potentially curative treatment (surgery, radiotherapy, chemotherapy or combinations thereof), of whom 85% remained relapse-free. Thirty-four patients did only get local treatment (surgery and/or radiotherapy) with curative potential, the relapse-free survival rate was 85%. We conclude that primary gastric lymphoma stage IE and IIE (N3 excluded) is often a truly localized disease that can be cured with local therapy.
对1970年至1985年间连续收治的72例原发性胃淋巴瘤患者的预后因素和治疗结果进行了分析。其中IE期37例，IIE期17例，IIES期3例，IV期15例。根据TNM系统进行了组织病理学重新评估和分类。我们发现，疾病播散（IV期）、浆膜侵犯（T3）、相邻器官受累（T4）和广泛的腹部淋巴结受累（N3）是不良预后因素。组织学恶性分级和淋巴上皮病变的出现均与无复发生存无显著相关性。46例“局限性局部”疾病（IE期、IIE期，排除N3）患者接受了潜在治愈性治疗（手术、放疗、化疗或联合治疗），其中85%无复发。34例患者仅接受了具有治愈潜力的局部治疗（手术和/或放疗），无复发生存率为85%。我们得出结论，原发性胃淋巴瘤IE期和IIE期（排除N3）通常是真正的局限性疾病，可通过局部治疗治愈。
