WILLOUGHBY D S, WATSON D W
J Bacteriol. 1964 Jun;87(6):1457-61. doi: 10.1128/jb.87.6.1457-1461.1964.
Willoughby, Donald S. (University of Minnesota, Minneapolis), and Dennis W. Watson. Host-parasite relationships among group A streptococci. II. Influence of sex on the susceptibility of inbred mice toward streptococcal infection. J. Bacteriol. 87:1457-1461. 1964-BALB/Sy mice showed marked sex differences in susceptibility to a strain of Streptococcus pyogenes type 18. Castration of the highly susceptible normal adult male increased their resistance 1,000-fold, which approximated that of normal female mice. Treatment of male mice with estrogen and stilbestrol did not affect their resistance significantly. Young, sexually immature male mice, 4 weeks old, were more resistant than mature males. Susceptibility of the resistant females was not affected by age or bilateral ovariectomy, but testosterone injections caused an increase in susceptibility. Treatment of male mice with estrogen and stilbestrol did not modify their resistance. Smears of peritoneal exudates from normal male mice after intraperitoneal injection of streptococci revealed rapid multiplication of the organisms. There was no evidence of multiplication in the resistant normal female and castrated male mice.
威洛比，唐纳德·S.（明尼苏达大学，明尼阿波利斯），以及丹尼斯·W.·沃森。A组链球菌的宿主-寄生虫关系。II. 性别对近交系小鼠链球菌感染易感性的影响。《细菌学杂志》87:1457 - 1461。1964年——BALB/Sy小鼠对18型化脓性链球菌菌株的易感性存在显著的性别差异。对高度易感的正常成年雄性小鼠进行阉割后，其抵抗力提高了1000倍，接近正常雌性小鼠的抵抗力。用雌激素和己烯雌酚处理雄性小鼠对其抵抗力没有显著影响。4周龄的幼年、性未成熟雄性小鼠比成年雄性更具抵抗力。抗性雌性小鼠的易感性不受年龄或双侧卵巢切除的影响，但注射睾酮会导致易感性增加。用雌激素和己烯雌酚处理雄性小鼠并没有改变它们的抵抗力。对正常雄性小鼠腹腔注射链球菌后，其腹腔渗出物涂片显示细菌迅速繁殖。在抗性正常雌性和阉割雄性小鼠中没有细菌繁殖的迹象。
