Norman J
Shackleton Department of Anaesthetics, General Hospital, Southampton.
Br J Anaesth. 1992 Oct;69(4):387-96. doi: 10.1093/bja/69.4.387.
The mathematical development of the equations needed to determine the plasma concentrations of drug in a one-compartment pharmacokinetic model are developed from first principles and are illustrated (with caution) by the use of morphine given by bolus or continuous i.v. injection or by a simulated i.m. injection. The equations allow the calculation of concentrations, given a knowledge of what drug is currently present, what are the sizes of the boluses by either i.m. or i.v. injection and what is the constant infusion rate. What happens when changes occur is also illustrated. The development illustrates the principles needed to apply to more complex models.
单室药代动力学模型中用于确定药物血浆浓度的方程的数学推导是从基本原理出发的，并（谨慎地）通过静脉推注、持续静脉注射或模拟肌肉注射给予吗啡的示例进行说明。这些方程在已知当前存在何种药物、肌肉注射或静脉注射的推注剂量大小以及恒定输注速率的情况下，可用于计算浓度。还说明了发生变化时的情况。该推导过程阐述了应用于更复杂模型所需的原理。
