Bhatavdekar J M, Patel D D, Giri D D, Karelia N H, Vora H H, Ghosh N, Shah N G, Trivedi S N, Balar D B
Division of Research, Gujarat Cancer Society, Asarwa, Ahmedabad, India.
Br J Cancer. 1992 Nov;66(5):977-80. doi: 10.1038/bjc.1992.395.
Plasma prolactin (PRL) and carcinoembryonic antigen (CEA) were measured by radioimmunoassay in 74 patients with adenocarcinoma of colon and rectum. The markers were correlated with disease stage, histological grade and progression/remission of disease. The circulating preoperative median PRL and CEA levels were significantly higher in colorectal cancer patients than in their respective controls. PRL was elevated in all Dukes stages and in all histological grades of the tumour whereas the rise in CEA was more pronounced in Dukes D. Out of 74 patients, 29% (21/74) developed recurrent disease and 31% (23/74) responded to the treatment. With regard to monitoring recurrence(s), the predictive value of PRL was 94% which was significantly greater than that of CEA which was only 62%. In patients who developed liver metastases PRL remained elevated whereas CEA showed more than 100-fold increase. Therefore, we feel that CEA is a better marker for monitoring patients who developed liver metastases. From our results, we suggest that PRL can be used as a better overall marker for detecting recurrence(s) in patients with colorectal adenocarcinoma.
采用放射免疫分析法对74例结肠直肠癌患者检测血浆催乳素（PRL）和癌胚抗原（CEA）。这些标志物与疾病分期、组织学分级及疾病进展/缓解情况相关。结直肠癌患者术前循环中PRL和CEA的中位水平显著高于各自的对照组。PRL在肿瘤的所有Dukes分期及所有组织学分级中均升高，而CEA在Dukes D期升高更为明显。74例患者中，29%（21/74）发生复发，31%（23/74）对治疗有反应。关于监测复发，PRL的预测价值为94%，显著高于CEA的62%。发生肝转移的患者中，PRL仍升高，而CEA升高超过100倍。因此，我们认为CEA是监测发生肝转移患者的更好标志物。根据我们的结果，我们建议PRL可作为检测结肠直肠腺癌患者复发的更好的总体标志物。
