兔实验性球孢子菌病中的补体结合滴度

COMPLEMENT-FIXATION TITERS IN EXPERIMENTAL COCCIDIOIDOMYCOSIS IN RABBITS.

作者信息

BROSBE E A, KIETZMAN J N, KURNICK N B

出版信息

J Bacteriol. 1964 Jul;88(1):233-41. doi: 10.1128/jb.88.1.233-241.1964.

DOI:10.1128/jb.88.1.233-241.1964

PMID:14197893

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC277282/

Abstract

Brosbe, Edwin A. (Veterans Administration Hospital, Long Beach, Calif.), Jewell N. Kietzman, and Nathaniel B. Kurnick. Complement-fixation titers in experimental coccidioidomycosis. J. Bacteriol. 88:233-241. 1964.-The course of experimental coccicioidomycosis in rabbits was followed with complement-fixation (CF) tests. Uniformity of complement-fixing antibody response to large infective doses was observed, and levels as high as 1:4,096 in the New Zealand albino and 1:16,384 in the Dutch rabbit were attained. Mortality reflected the size of the inoculum rather than the level of CF titer. Animals receiving additional challenges displayed no marked elevation in titer, although high titers persisted. Nitrogen mustard, for the most part, did not influence the CF titer.

摘要

布罗斯比，埃德温·A.（加利福尼亚州长滩退伍军人管理局医院），朱厄尔·N.基茨曼，以及纳撒尼尔·B.库尔尼克。实验性球孢子菌病中的补体结合滴度。《细菌学杂志》88:233 - 241。1964年。——通过补体结合（CF）试验追踪了兔子实验性球孢子菌病的病程。观察到对大感染剂量的补体结合抗体反应具有一致性，新西兰白兔的抗体滴度高达1:4096，荷兰兔的高达1:16384。死亡率反映的是接种物的大小而非补体结合滴度水平。接受额外挑战的动物，尽管高滴度持续存在，但滴度没有明显升高。氮芥在很大程度上不影响补体结合滴度。