Illum N, Korf H W, Julian K, Rasmussen T, Herning M, Krabbe S
Department of Pediatrics, Hvidovre Hospital, Copenhagen, Denmark.
Br J Ophthalmol. 1992 Sep;76(9):574-6. doi: 10.1136/bjo.76.9.574.
Uveoretinitis was observed in a 9-year-old girl 6 months prior to the clinical appearance of a pineal tumour. Surgical removal was not successful but biopsy revealed a parenchymal neoplasm with differentiated pinealocytes and absent mitotic activity. Some of the tumour cells contained S-antigen, rhodopsin, and serotonin. Systemic glucocorticoid therapy followed by radiation therapy caused considerable reduction in size of the tumour and a complete normalisation of all eye symptoms. This report demonstrates for the first time that a pineocytoma can occur together with uveoretinitis in humans. The latter resembles the experimentally induced autoimmune uveoretinitis described in animals. It is speculated that the retinitis might reflect an autoimmune response to S-antigen present in some tumour cells of the pineocytoma.
在一名9岁女孩身上，葡萄膜视网膜炎在松果体肿瘤临床表现出现前6个月就已被观察到。手术切除未成功，但活检显示为一种实质性肿瘤，有分化的松果体细胞且无有丝分裂活性。部分肿瘤细胞含有S抗原、视紫红质和血清素。全身糖皮质激素治疗后接着进行放射治疗，使肿瘤大小显著缩小，所有眼部症状完全恢复正常。本报告首次证明人类松果体细胞瘤可与葡萄膜视网膜炎同时发生。后者类似于在动物中描述的实验性诱导自身免疫性葡萄膜视网膜炎。据推测，视网膜炎可能反映了对松果体细胞瘤某些肿瘤细胞中存在的S抗原的自身免疫反应。
