哌啶对大鼠肌梭的作用。
The action of piperidine on muscle spindles in the rat.
作者信息
Kidd G L, Kucera J
出版信息
Eur J Pharmacol. 1977 Jun 15;43(4):353-9. doi: 10.1016/0014-2999(77)90041-3.
Piperidine hydrochloride induced discharge in primary and secondary endings of muscle spindles in rat tailbase muscle preparations. The threshold concentration for primary endings (2.0 X 10(-5) g/ml) was below that for secondary endings (4.0 X 10(-5) g/ml). The effect of piperidine was antagonised by tubocurarine but not by atropine. The action of piperidine on primary and secondary endings responding to 'ramp-and-hold' stretch was predominantly on the static component of excitation, and usually in the absence of any concomitant enhancement of the dynamic effect. This effect was opposite to that induced by succinylcholine. A possible action of piperidine at cholinoceptive sites of the nicotinic type and associated with gamma-trial fusimotor terminals is discussed.
盐酸哌啶可引起大鼠尾基部肌肉制备物中肌梭初级和次级终末的放电。初级终末的阈浓度（2.0×10⁻⁵ g/ml）低于次级终末的阈浓度（4.0×10⁻⁵ g/ml）。哌啶的作用可被筒箭毒碱拮抗，但不能被阿托品拮抗。哌啶对响应“斜坡-保持”拉伸的初级和次级终末的作用主要作用于兴奋的静态成分，且通常在不伴随动态效应增强的情况下发生。这种效应与琥珀酰胆碱诱导的效应相反。文中讨论了哌啶在烟碱型胆碱能感受位点可能的作用以及与γ-运动神经梭外肌运动终末的关联。
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