Gao X, Serjeantson S W
Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra.
Eur J Immunogenet. 1992 Oct;19(5):263-72. doi: 10.1111/j.1744-313x.1992.tb00069.x.
The relative distributions of 12 HLA-DR6-related HLA-DRB1 alleles in indigenous populations of Australia, Melanesia, Polynesia, Micronesia, and northern and southern China have been determined by analysis of nucleotide sequence polymorphisms in 364 examples of HLA-DR6 positive chromosomes. Oligonucleotide hybridizations of polymerase chain reaction products of HLA-DQA1, DQB1, DRB1 and DRB3 genes generated 24 HLA-DR6-related haplotypes. The study aimed to determine the regional distribution of DR,DQ haplotypes associated with three novel HLA-DR6 alleles, namely DRB11408, 1409, and 1410, known to occur in Australian Aborigines, to gain further insights into the molecular phylogeny of these alleles. DRB11408 was the most common HLA-DR6 subtype in Oceania, although it was not detected in Chinese. In Australian Aborigines and Papua New Guinean highlanders, DRB11408 was associated with DRB30202, while in Polynesians and Micronesians it was associated with DRB30101. The different haplotype arrangements, together with the near absence of DRB11408 in coastal Melanesians, suggest the possibility that two independent mutations have generated DRB11408 in Australia and Oceania. DRB11409 and 1410 alleles were confined to Australian Aborigines, while DRB11407 was found exclusively in Melanesians; DRB11401 was the only HLA-DR6 allele represented in all study populations. The population-specific HLA-DR6 alleles and haplotypes have important implications for unrelated bone-marrow donor registries in Australia and Oceania.
通过对364个HLA - DR6阳性染色体样本的核苷酸序列多态性分析，已确定了澳大利亚、美拉尼西亚、波利尼西亚、密克罗尼西亚以及中国北方和南方的原住民群体中12种与HLA - DR6相关的HLA - DRB1等位基因的相对分布情况。HLA - DQA1、DQB1、DRB1和DRB3基因的聚合酶链反应产物的寡核苷酸杂交产生了24种与HLA - DR6相关的单倍型。该研究旨在确定与三种新的HLA - DR6等位基因（即DRB11408、1409和1410，已知存在于澳大利亚原住民中）相关的DR、DQ单倍型的区域分布，以进一步深入了解这些等位基因的分子系统发育。DRB11408是大洋洲最常见的HLA - DR6亚型，不过在中国未检测到。在澳大利亚原住民和巴布亚新几内亚高地人中，DRB11408与DRB30202相关，而在波利尼西亚人和密克罗尼西亚人中，它与DRB30101相关。不同的单倍型排列，以及沿海美拉尼西亚人几乎不存在DRB11408的情况，表明在澳大利亚和大洋洲可能有两个独立的突变产生了DRB11408。DRB11409和1410等位基因仅限于澳大利亚原住民，而DRB11407仅在美拉尼西亚人中发现；DRB11401是所有研究群体中唯一出现的HLA - DR6等位基因。特定人群的HLA - DR6等位基因和单倍型对澳大利亚和大洋洲无关骨髓供体登记处具有重要意义。
