[Effect of combined administration of phenobarbital and 2-methyl-3-(o-chlorphenyl)-quinazolone-4 with hydrocortisone on the dynamics of blood corticosteroid content and ATPase activity of rat brain].

Tests conducted on rats evidenced that with combined use of hydrocortisone, 2-methyl-3-(o-chlorphenyl)-quinazolone-4 and phenobarbital the development of the hypnotic effect and the level of the blood corticosteroids were inversely proportional. The relation between the hypnotic effect and inhibition of the ATP-ase activity of the cerebral tissue homogenates in rats was observed only in experiments with phenobarbital.