Semenov E V, Krylov S S, Petrov A N
Biull Eksp Biol Med. 1977 Sep;84(9):306-9.
The effect of benactyzine (the central cholinolytic) in a dose of 40 mg/kg and arecoline (cholinomimetic) in a dose of 2.5 mg/kg on the activity of Mg2+-dependent ATP-ase and the content of Ca2+ and Mg2+ ions in the brain was studied in rats. It was shown that benactyzine and arecoline evoked a biphasic change in the activity of the enzyme and the electrolyte content. A conclusion was drawn that the enzyme inhibition was connected with the accumulation of Ca2+ ions in the brain tissue, whereas its inhibition--with the Mg2+ ion accumulation. It is supposed that throught these effects benactyzine and arecoline influenced the release and retention of the neuromediators in the tissue depot.
研究了给予大鼠40毫克/千克剂量的苯那嗪（中枢性抗胆碱药）和2.5毫克/千克剂量的槟榔碱（拟胆碱药）对大脑中镁离子依赖性ATP酶活性以及钙和镁离子含量的影响。结果表明，苯那嗪和槟榔碱引起了该酶活性和电解质含量的双相变化。得出的结论是，酶活性的抑制与脑组织中钙离子的积累有关，而酶活性的增强则与镁离子的积累有关。据推测，苯那嗪和槟榔碱通过这些作用影响了神经递质在组织储存库中的释放和保留。
