Rusovan A, Kanje M
Department of Animal Physiology, University of Lund, Sweden.
Neuroreport. 1992 Sep;3(9):813-4. doi: 10.1097/00001756-199209000-00023.
We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmotic minipumps. Magnetic field exposure increased regeneration distances in vehicle perfused nerves. This enhancement was blocked by perfusion with D600 at a concentration which alone failed to affect outgrowth of nerve fibres, lending support to the idea that Ca2+ fluxes could be involved in mediating the biological actions of magnetic fields.
我们发现，如果将大鼠暴露于50赫兹的正弦磁场中，大鼠坐骨神经的再生会受到刺激。在本研究中，我们调查了一种钙离子拮抗剂——甲氧基维拉帕米（D600）对这种反应的影响。通过植入的渗透微型泵将D600施用于神经的再生段。磁场暴露增加了用赋形剂灌注的神经的再生距离。在单独使用时未能影响神经纤维生长的浓度下，用D600灌注可阻断这种增强作用，这支持了钙离子通量可能参与介导磁场生物作用的观点。
