Han M
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309.
Semin Cancer Biol. 1992 Aug;3(4):219-28.
Recent studies of genetically isolated mutants in Caenorhabditis elegans and Drosophila have revealed ras functions in developmental pattern formation. The ras proteins act as genetic switches to determine cell fates between two alternative choices during C elegans vulval development (vulval versus hypodermal cells) and during Drosophila eye development (R7 versus cone cell). In both cases, ras proteins act downstream of a receptor tyrosine kinase in a signal transduction pathway that mediates cell-cell interactions. These genetic systems may allow the further elucidation of ras-mediated developmental regulatory pathways.
最近对秀丽隐杆线虫和果蝇中基因分离突变体的研究揭示了ras在发育模式形成中的功能。在秀丽隐杆线虫的外阴发育过程（外阴细胞与皮下细胞）以及果蝇眼睛发育过程（R7细胞与圆锥细胞）中，ras蛋白作为基因开关，决定细胞在两种替代选择之间的命运。在这两种情况下，ras蛋白都在介导细胞间相互作用的信号转导途径中的受体酪氨酸激酶下游起作用。这些遗传系统可能有助于进一步阐明ras介导的发育调控途径。
