植物肿瘤提取物产生的组胺保护作用。感染根癌的番茄植株的活性成分。
HISTAMINE PROTECTION PRODUCED BY PLANT TUMOUR EXTRACTS. THE ACTIVE PRINCIPLE OF TOMATO PLANTS INFECTED WITH GROWN-GALL.
作者信息
CALAM D H, CALLOW R K
出版信息
Br J Pharmacol Chemother. 1964 Jun;22(3):486-98. doi: 10.1111/j.1476-5381.1964.tb01703.x.
Abstract
Guinea-pigs were protected against the lethal effects of a histamine aerosol by intraperitoneal injection of stable extracts of normal tomato plants and of tomato plants infected with crown-gall tumours. The protection was short-lasting. No difference was observed between the activities of extracts of normal and of infected plants. The active principle of the extracts was isolated, and identified as the steroid alkaloid glycoside, tomatine.
摘要
通过腹腔注射正常番茄植株和感染冠瘿瘤的番茄植株的稳定提取物，豚鼠对组胺气雾剂的致死作用具有抵抗力。这种保护作用持续时间较短。未观察到正常植株提取物和感染植株提取物的活性有差异。提取物的活性成分被分离出来，并鉴定为甾体生物碱糖苷番茄碱。
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3
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6
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Toxicol Appl Pharmacol. 1961 Jan;3:39-48. doi: 10.1016/0041-008x(61)90006-0.
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J Biol Chem. 1958 May;232(1):315-22.
8
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