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HISTAMINE PROTECTION PRODUCED BY PLANT TUMOUR EXTRACTS. THE ACTIVE PRINCIPLE OF TOMATO PLANTS INFECTED WITH GROWN-GALL.植物肿瘤提取物产生的组胺保护作用。感染根癌的番茄植株的活性成分。
Br J Pharmacol Chemother. 1964 Jun;22(3):486-98. doi: 10.1111/j.1476-5381.1964.tb01703.x.
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引用本文的文献

1
Anti-inflammatory activity of the steroid alkaloid glycoside, toatine.甾体生物碱苷类化合物托替宁的抗炎活性。
Br J Pharmacol. 1969 Nov;37(3):748-55. doi: 10.1111/j.1476-5381.1969.tb08514.x.
2
Histamine protection produced by oak gall extracts.没食子提取物产生的组胺保护作用。
Br J Pharmacol Chemother. 1966 Mar;26(3):697-703. doi: 10.1111/j.1476-5381.1966.tb01849.x.

本文引用的文献

1
Protection by flavonoids against histamine shock.类黄酮对组胺休克的保护作用。
Proc Soc Exp Biol Med. 1951 Mar;76(3):540-2. doi: 10.3181/00379727-76-18549.
2
[A new antihistamine of plant origin].一种新型植物源抗组胺药。
Arch Int Pharmacodyn Ther. 1950 Dec;84(2-3):276-82.
3
The metabolism of acetyl digitoxin in the rat.乙酰洋地黄毒苷在大鼠体内的代谢
J Pharmacol Exp Ther. 1960 Apr;128:329-32.
4
Histamine protection in guinea-pigs produced by plant tumour extracts.植物肿瘤提取物对豚鼠的组胺保护作用。
Br J Pharmacol Chemother. 1962 Feb;18(1):87-100. doi: 10.1111/j.1476-5381.1962.tb01153.x.
5
Biological activity in steroids possessing nitrogen atoms. II. Steroidal alkaloids.含氮甾体的生物活性。II. 甾体生物碱。
J Pharm Pharmacol. 1962 Aug;14:469-95. doi: 10.1111/j.2042-7158.1962.tb11127.x.
6
Some pharmacologic and toxicologic properties of tomatine and its derivatives.
Toxicol Appl Pharmacol. 1961 Jan;3:39-48. doi: 10.1016/0041-008x(61)90006-0.
7
The metabolites of cardiac glycosides in human urine.
J Biol Chem. 1958 May;232(1):315-22.
8
[Cholesterol tomatide; a new molecular formation for the analysis and preparative extraction of steroids].[胆固醇番茄苷；一种用于甾体分析和制备提取的新分子结构]
Hoppe Seylers Z Physiol Chem. 1957;308(2-4):122-6.
9
Bronchoconstrictor agents and their antagonists in the intact guinea-pig.完整豚鼠体内的支气管收缩剂及其拮抗剂
Arch Int Pharmacodyn Ther. 1956 Jun 1;106(4):371-80.
10
[Antihistaminic effects of plant tumors].[植物肿瘤的抗组胺作用]
Arch Int Pharmacodyn Ther. 1952;90(1):93-100.

植物肿瘤提取物产生的组胺保护作用。感染根癌的番茄植株的活性成分。

HISTAMINE PROTECTION PRODUCED BY PLANT TUMOUR EXTRACTS. THE ACTIVE PRINCIPLE OF TOMATO PLANTS INFECTED WITH GROWN-GALL.

作者信息

CALAM D H, CALLOW R K

出版信息

Br J Pharmacol Chemother. 1964 Jun;22(3):486-98. doi: 10.1111/j.1476-5381.1964.tb01703.x.

DOI:10.1111/j.1476-5381.1964.tb01703.x
PMID:14211679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703940/
Abstract

Guinea-pigs were protected against the lethal effects of a histamine aerosol by intraperitoneal injection of stable extracts of normal tomato plants and of tomato plants infected with crown-gall tumours. The protection was short-lasting. No difference was observed between the activities of extracts of normal and of infected plants. The active principle of the extracts was isolated, and identified as the steroid alkaloid glycoside, tomatine.

摘要

通过腹腔注射正常番茄植株和感染冠瘿瘤的番茄植株的稳定提取物，豚鼠对组胺气雾剂的致死作用具有抵抗力。这种保护作用持续时间较短。未观察到正常植株提取物和感染植株提取物的活性有差异。提取物的活性成分被分离出来，并鉴定为甾体生物碱糖苷番茄碱。