Lazarenko L N, Spivak N Ia, Umanskiĭ V Iu, Vikhot' N E, Ivanenko V K
Biull Eksp Biol Med. 1992 Jul;114(7):63-6.
In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases. Introduction of homologous alpha-IFN in the dose of 1 x 10(3) u/mouse leads to enhancing macrophage bactericidity of the animals infected, inhibits their 5-nucleotidase activity and enhances adenosine desaminase one. Influence of alpha-IFN on the activity of adenosine metabolism enzymes in macrophages can be considered one of the most important mechanisms of its modulating effect in bacterial infections.
在葡萄球菌感染时，巨噬细胞的功能能力会发生变化：其依赖氧的杀菌能力和腺苷脱氨酶活性降低，而5-核苷酸酶能力增强。以1×10(3)单位/小鼠的剂量注射同源α-干扰素，可增强感染动物巨噬细胞的杀菌能力，抑制其5-核苷酸酶活性，并增强腺苷脱氨酶活性。α-干扰素对巨噬细胞中腺苷代谢酶活性的影响可被视为其在细菌感染中调节作用的最重要机制之一。
