Goncharova E N, Timoshin S S, Bespalova Zh D, Murzina N B
Biull Eksp Biol Med. 1992 Jul;114(7):73-5.
The effect of atrial natriuretic peptides synthetic analog AP II on adrenal zona glomerulosa and zona fasciculata physiological regeneration have been studied on male rats. The 3H-thymidine incorporation into DNA in adrenal cortical cells was evaluated in 4 and 24 h after intraperitoneal injection of 10 or 100 mcg/kg AP II. Besides, we have investigated the influence of AP II on adrenal cortical cells karyometric parameter in 4 and 24 h and aldosterone plasma concentration in 1 h after injection. 10 mcg/kg AP II increased the fraction of labelled nuclei in zona glomerulosa and decreased the aldosterone plasma level. No significant changes were seen in zona fasciculata cells proliferation. 100 mcg/kg AP II inhibited the DNA synthesis process in adrenal zona fasciculata, but had no significant influence on zona glomerulosa physiological regeneration and aldosterone plasma concentration. No nuclear morphometric parameter changes were observed in adrenal glomerulosa and fasciculata cells of AP II--treated animals.
在雄性大鼠身上研究了心房利钠肽合成类似物AP II对肾上腺球状带和束状带生理再生的影响。在腹腔注射10或100微克/千克AP II后的4小时和24小时，评估肾上腺皮质细胞中3H-胸腺嘧啶核苷掺入DNA的情况。此外，我们还研究了AP II在注射后4小时和24小时对肾上腺皮质细胞核测量参数的影响，以及在注射后1小时对血浆醛固酮浓度的影响。10微克/千克AP II增加了球状带中标记细胞核的比例，并降低了血浆醛固酮水平。束状带细胞增殖未见明显变化。100微克/千克AP II抑制了肾上腺束状带中的DNA合成过程，但对球状带生理再生和血浆醛固酮浓度无显著影响。在接受AP II治疗的动物的肾上腺球状带和束状带细胞中未观察到核形态测量参数的变化。
