Gemba M, Nishimura K
Jpn J Pharmacol. 1977 Apr;27(2):205-11. doi: 10.1254/jjp.27.205.
Effects of three diuretics on the urinary Ca2+ excretion and on the microsomal Ca2+-activated ATPase were examined in the rat kidney. Furosemide and bumetanide increased Na+, K+, and Ca2+ excretion in the rats. Acetazolamide increased Na+ and K+ excretion but not Ca2+. Urinary inorganic phosphate excretion was not affected during the administration of acetazolamide. It is suggested that acetazolamide inhibits Na+ transport without affecting Ca2+ reabsorption in the rat nephron. Microsomal ATPase of the rat kidney cortex was stimulated by Ca2+ or Mg2+ alone and an additive effect of the two cations was not observed. Microsomal ATPase activated by Ca2+ or Mg2+ was not inhibited by furosemide, bumetanide, and acetazolamide. These data suggest that the inhibitory effect of furosemide and bumetanide on the Ca2+ reabsorption is not related to the inhibition of Ca2+-activated ATPase.
在大鼠肾脏中研究了三种利尿剂对尿钙排泄及微粒体钙激活ATP酶的影响。速尿和布美他尼增加了大鼠的钠、钾和钙排泄。乙酰唑胺增加了钠和钾排泄，但不增加钙排泄。在给予乙酰唑胺期间，尿无机磷排泄未受影响。提示乙酰唑胺在大鼠肾单位中抑制钠转运而不影响钙重吸收。大鼠肾皮质微粒体ATP酶仅受钙或镁刺激，未观察到两种阳离子的相加作用。钙或镁激活的微粒体ATP酶不受速尿、布美他尼和乙酰唑胺抑制。这些数据提示速尿和布美他尼对钙重吸收的抑制作用与钙激活ATP酶的抑制无关。
