Muchmore E A
Department of Medicine, University of California, San Diego, VA Medical Center 92161.
Glycobiology. 1992 Aug;2(4):337-43. doi: 10.1093/glycob/2.4.337.
The changes in expression of sialic acids in Sprague-Dawley rats in the prenatal and early postnatal time period have been examined in multiple organs, both visceral and non-visceral. In all organs examined, there is a dramatic increase in both N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) shortly after birth. The bulk of the sialic acid is present in the ganglioside fraction in all tissues examined. As total amounts of sialic acid present in gangliosides decrease, the proportion present in the low molecular weight cytosolic fraction increases. A curious observation is that Neu5Ac hydroxylase activity is present at the time of the increase in sialic acid, but its activity does not correlate with Neu5Gc expression after the early postnatal period. This implies that Neu5Gc expression has another level of regulation besides CMP-Neu5Ac hydroxylase activity.
已对产前和产后早期的斯普拉格-道利大鼠多个内脏和非内脏器官中唾液酸的表达变化进行了研究。在所有检查的器官中，出生后不久N-乙酰神经氨酸（Neu5Ac）和N-羟乙酰神经氨酸（Neu5Gc）均显著增加。在所有检查的组织中，大部分唾液酸存在于神经节苷脂部分。随着神经节苷脂中唾液酸总量的减少，低分子量胞质部分中唾液酸的比例增加。一个有趣的现象是，在唾液酸增加时存在Neu5Ac羟化酶活性，但在出生后早期之后其活性与Neu5Gc表达不相关。这意味着除了CMP-Neu5Ac羟化酶活性外，Neu5Gc表达还有另一水平的调节。
