Karper L P, Salloway S P, Seibyl J P, Krystal J H
Yale University School of Medicine, Department of Psychiatry, West Haven VA Medical Center, CT 06516.
J Neuropsychiatry Clin Neurosci. 1992 Fall;4(4):454-7. doi: 10.1176/jnp.4.4.454.
Two patients with prolonged postictal encephalopathy lasting 63 and 72 hours, respectively, following seizures with clozapine are reported. Clozapine alters the EEG in a majority of patients treated, with seizure frequency as high as 5-10% in doses above 600 mg/d. Prolonged postictal encephalopathy following a clozapine-induced seizure has not been previously reported but may be an important side effect of this medication. Pharmacologic and clinical issues are discussed.
