Lee Jimmy, Powell Valerie, Remington Gary
Department of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore; Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Schizophr Res. 2014 Aug;157(1-3):134-6. doi: 10.1016/j.schres.2014.04.038. Epub 2014 Jun 3.
This study investigated the MPV of patients with major psychoses before and after 1year of clozapine exposure. Data were obtained from chart reviews of patients who were initiated on clozapine at the Centre of Addiction and Mental Health (CAMH) in Toronto. 100 patients were eligible for this study; 65 remained on clozapine after 1year. Prior to clozapine initiation, MPV was 10.79±0.91fL and there was no difference in MPV after 1year of clozapine exposure (p=0.777). We found high MPV in patients with schizophrenia and related psychoses, which was unaltered after 1year of clozapine treatment.
本研究调查了服用氯氮平1年前后患有重度精神病患者的平均血小板体积（MPV）。数据来自多伦多成瘾与心理健康中心（CAMH）开始服用氯氮平患者的病历回顾。100名患者符合本研究条件；1年后65名患者仍在服用氯氮平。在开始服用氯氮平之前，MPV为10.79±0.91飞升，服用氯氮平1年后MPV没有差异（p=0.777）。我们发现精神分裂症及相关精神病患者的MPV较高，氯氮平治疗1年后该指标未发生改变。
