Burguera M, Burguera J L, Alarcón O M, Dávila D, Carrasco H A, Contreras de Peñaloza N
Departamento de Quimica, Facultad de Ciencias, Universidad de Los Andes, Venezuela.
J Trace Elem Electrolytes Health Dis. 1992 Jun;6(2):91-7.
Sodium, potassium, chloride, calcium, inorganic phosphorus (Pi) and magnesium contents in the serum of 75 myocardiopathic chagasic patients together with that in 29 healthy controls were determined. Blood samples were taken by catheterization from the superior cava vein (SCV), coronary sinus (CS), pulmonary artery (PA) and a peripheral artery, usually the femoral (FA). The results show that the average serum sodium, potassium, chloride, calcium and PI were invariably different in most samples, except the levels of potassium in SCV and Pi levels in FA. The serum concentration of magnesium was significantly different only in the blood of CS. In general one can observe that in the chagasic patients the serum sodium, chloride and calcium tend to diminish while serum potassium, Pi and magnesium tend to increase, especially in CS blood. The coronary gradient indicates that sodium, chloride and calcium tend to deposit in heart tissues, whereas the other elements (potassium, magnesium and Pi) tend to be released from this tissue. The systemic and peripheric gradients suggest that the chemical elements under study tend either to deposit in/or be released from different tissues depending on the course of development of the chagasic myocardiopathy.
测定了75例恰加斯病性心肌病患者血清中的钠、钾、氯、钙、无机磷（Pi）和镁含量，并与29例健康对照者进行了比较。通过导管从颈上腔静脉（SCV）、冠状窦（CS）、肺动脉（PA）和一条外周动脉（通常为股动脉（FA））采集血样。结果显示，除了SCV中的钾水平和FA中的Pi水平外，大多数样本中血清钠、钾、氯、钙和Pi的平均水平始终存在差异。镁的血清浓度仅在CS血液中存在显著差异。总体而言，可以观察到恰加斯病患者血清钠、氯和钙趋于减少，而血清钾、Pi和镁趋于增加，尤其是在CS血液中。冠状动脉梯度表明钠、氯和钙倾向于沉积在心脏组织中，而其他元素（钾、镁和Pi）倾向于从该组织中释放出来。全身和外周梯度表明，所研究的化学元素根据恰加斯病性心肌病的发展过程，倾向于在不同组织中沉积或从不同组织中释放出来。
