Burguera J L, Burguera M, Alarcón O M, Cañada de Zunzunegui M, Carrasco H A, Dávila D, Reinosa J
Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, Venezuela.
J Trace Elem Electrolytes Health Dis. 1988 Dec;2(4):215-9.
Zinc, iron and copper content in serum of 75 myocardiopathic chagasic patients together with that in 29 healthy controls were determined. Blood samples were taken by catheterization from the superior cava vein, coronary sinus, pulmonary artery and a peripheral artery, usually the femoral. In general, serum zinc and iron levels tend to diminish in chagasic patients, while serum copper levels tend to increase. The coronary, systemic and peripheric gradients indicate that all these metal elements tend to deposit in heart tissue. Although zinc and iron tend to be deposited also in liver and other tissues, copper is released from them into the blood stream. Further studies should determine the requirement of these metal species in heart and other tissues of experimental animals in order to obtain more conclusive information about the cause of the serum metal impairment observed here.
测定了75例恰加斯病性心肌病患者血清中的锌、铁和铜含量，并与29名健康对照者进行了比较。通过导管从颈上腔静脉、冠状窦、肺动脉和一条外周动脉（通常是股动脉）采集血样。总体而言，恰加斯病患者血清锌和铁水平往往降低，而血清铜水平往往升高。冠状动脉、全身和外周的梯度表明，所有这些金属元素都倾向于沉积在心脏组织中。尽管锌和铁也倾向于沉积在肝脏和其他组织中，但铜会从这些组织释放到血流中。进一步的研究应确定实验动物心脏和其他组织中这些金属物质的需求，以便获得关于此处观察到的血清金属损伤原因的更确凿信息。
