Murphy C P, Cox R L, Harden E A, Stevens D A, Heye M M, Herzig R H
University of Louisville Bone Marrow Transplant Program.
Bone Marrow Transplant. 1992 Oct;10(4):383-5.
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy. Continuous bladder irrigation of a 1% alum solution is a simple and generally safe method of chemical cautery to treat the bleeding urothelium. We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum. All patients had significant renal insufficiency. We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.
出血性膀胱炎是环磷酰胺治疗的一种显著毒性作用。用1%明矾溶液持续膀胱冲洗是一种治疗出血性膀胱上皮的简单且通常安全的化学烧灼方法。我们报告了4例与铝水平升高相关的脑病病例以及1例在接受明矾持续膀胱冲洗时发生癫痫发作的患者。所有患者均有严重肾功能不全。我们建议肾功能损害患者谨慎使用明矾冲洗，并监测血清铝水平以防止铝过度蓄积和中毒。
