解偶联剂与线粒体解偶联的分子机制
Uncouplers and the molecular mechanism of uncoupling in mitochondria.
作者信息
Kessler R J, Vande Zande H, Tyson C A, Blondin G A, Fairfield J, Glasser P, Green D E
出版信息
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2241-5. doi: 10.1073/pnas.74.6.2241.
Abstract
Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.
摘要
解偶联剂是具有质子载体和离子载体能力的分子，它们介导阳离子的偶联循环转运——这种转运优先于所有其他偶联过程。解偶联剂与生电离子载体形成含阳离子的复合物，从而增强阳离子的循环转运。解偶联的分子机制为偶联机制提供了重要线索。
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本文引用的文献
1
Stoichiometric relationships between mitochondrialion accumulation and oxidative phosphorylation.线粒体离子积累与氧化磷酸化之间的化学计量关系。
Biochem Biophys Res Commun. 1963 Jun 20;11:441-6. doi: 10.1016/0006-291x(63)90089-5.
2
The catalytic effect of 2,4-dinitrophenol on adenosinetriphosphate hydrolysis by cell particles and soluble enzymes.2,4-二硝基苯酚对细胞颗粒及可溶性酶水解三磷酸腺苷的催化作用。
J Biol Chem. 1953 Mar;201(1):357-70.
3
Proton conductors in the respiratory chain and artificial membranes.呼吸链和人工膜中的质子导体。
Nature. 1967 Nov 18;216(5116):718-9. doi: 10.1038/216718a0.
4
Uncouplers of rat-liver mitochondrial oxidative phosphorylation.大鼠肝脏线粒体氧化磷酸化的解偶联剂
Biochem J. 1965 Dec;97(3):658-62. doi: 10.1042/bj0970658.
5
Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria.氧化磷酸化与线粒体膜电位的偶联机制。
Nature. 1969 Jun 14;222(5198):1076-8. doi: 10.1038/2221076a0.
6
The structure of nigericin.尼日利亚菌素的结构。
Biochem Biophys Res Commun. 1968 Oct 10;33(1):29-31. doi: 10.1016/0006-291x(68)90249-0.
7
The isolation and properties of a peptide ionophore from beef heart mitochondria.从牛心线粒体中分离出一种肽离子载体及其特性。
Biochem Biophys Res Commun. 1971 Apr 2;43(1):28-35. doi: 10.1016/s0006-291x(71)80080-3.
8
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Arch Biochem Biophys. 1970 Nov;141(1):141-6. doi: 10.1016/0003-9861(70)90116-5.
9
Conformational model of active transport.主动运输的构象模型。
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10
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