Young J H, Blondin G A, Vanderkooi G, Green D E
Proc Natl Acad Sci U S A. 1970 Oct;67(2):550-9. doi: 10.1073/pnas.67.2.550.
A model of active transport of monovalent cations in mitochondria is developed. The model is based on the coupling of electron transfer to the generation of a metastable protein conformation which in turn leads to the generation of an asymmetric surface charge, a membrane potential, and a redistribution of diffusible ions across the inner mitochondrial membrane. The ions at all times move spontaneously down an electrochemical potential gradient in this model so that there is no need to invoke the concept of an ion pump. It is shown that a wide variety of experimental facts can be rationalized in terms of the present model.
建立了线粒体中单价阳离子主动运输的模型。该模型基于电子传递与亚稳态蛋白质构象生成的耦合，这反过来又导致不对称表面电荷、膜电位的产生以及可扩散离子在线粒体内膜上的重新分布。在该模型中，离子始终沿电化学势梯度自发移动，因此无需引入离子泵的概念。结果表明，根据目前的模型可以合理解释各种各样的实验事实。
