DAMMIN G J
Bull World Health Organ. 1964;31(1):29-32.
Consecutive deaths of children in Guatemala City were investigated with a view to discovering possible correlations between malnutrition, enteric infection and diarrhoeal disease. Malnutrition and diarrhoeal disease were common in this childhood population. It was found that enteric pathogens did not occur in large enough numbers to constitute a major cause of diarrhoeal disease. Children with malnutrition and diarrhoeal disease not associated with enteric pathogens were noted to have a non-ulcerative inflammatory reaction in the jejunal mucosa. The jejunum of these children contained an abnormally large population of bacteria, not recognized as bacterial pathogens, and whose presence may be the basis of diarrhoeal disease in children suffering from malnutrition.The author suggests that diarrhoeal disease in association with malnutrition be treated with antibiotics, fluids and electrolytes as a short-term measure, and by raising the nutritional standard as a long-term measure.
对危地马拉城儿童连续死亡事件展开调查，旨在发现营养不良、肠道感染与腹泻病之间可能存在的关联。营养不良和腹泻病在该儿童群体中很常见。研究发现，肠道病原体数量不足以构成腹泻病的主要病因。注意到患有营养不良和与肠道病原体无关的腹泻病的儿童，其空肠黏膜有非溃疡性炎症反应。这些儿童的空肠中存在数量异常多的细菌，这些细菌未被认定为病原菌，其存在可能是营养不良儿童腹泻病的发病基础。作者建议，作为短期措施，对伴有营养不良的腹泻病采用抗生素、液体和电解质进行治疗，作为长期措施，则提高营养标准。
