Vince J D
Department of Clinical Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.
P N G Med J. 1995 Dec;38(4):262-71.
National data for diarrhoeal disease in children can only be used as a very rough guide to morbidity and mortality, since they are based on incomplete reporting. Furthermore, when only one diagnosis per attendance, admission or cause of death is recorded, the true importance of diarrhoea as a cause of morbidity and mortality may be obscured. This may in part explain discrepancies between figures recorded in national and hospital statistics and those recorded in detailed studies of diarrhoeal admissions. While there appear to be quite marked differences in the relative importance of diarrhoea in different parts of the country, and while diarrhoeal disease is less of a scourge than in some other parts of the world, it is nevertheless a major cause of attendance at health facilities, the second or third most common cause of admission to many of the hospitals in the country, and a significant and often preventable cause of death. Limited studies of diarrhoeal aetiology indicate the major importance of rotavirus, Shigella and enteropathogenic and enterotoxigenic Escherichia coli. The control of diarrhoeal diseases in children is based not only on early and appropriate treatment, but also on preventive strategies. These include breastfeeding (which has saved the lives of many thousands of Papua New Guinean children and which is once again under threat), ensuring good host defence by good nutrition, immunization and early treatment of childhood illness, and ensuring satisfactory sanitation and hygiene. Increasing fluid intake to prevent dehydration remains the most important part of the early management of acute diarrhoeal disease. In the management of children with dehydration, UNICEF glucose-based oral rehydration therapy is widely available but not used as well as it should be. There are significant advantages in cereal-based oral rehydration solutions, and the use of such solutions, locally prepared, should be encouraged. Breastfeeding should be continued during episodes of diarrhoea, unless there is the specific contraindication of lactose intolerance. In all events the child's nutritional intake should be maintained and if possible increased during episodes of diarrhoea. There are specific indications for the use of antibiotics in the management of children with diarrhoea. They should not be used, and may be harmful, in the absence of these indications. Persistent diarrhoea--lasting more than 14 days--is associated with a high mortality and severe malnutrition. It is therefore important that children whose diarrhoea is prolonged for more than 7 days are managed appropriately, using the standard guidelines.
由于国家层面的儿童腹泻病数据是基于不完整报告得出的,因此只能作为发病率和死亡率的大致参考。此外,若每次就诊、入院或死亡原因仅记录一种诊断结果,腹泻作为发病和死亡原因的真正重要性可能会被掩盖。这在一定程度上可以解释国家统计数据和医院统计数据中记录的数字与腹泻入院详细研究中记录的数字之间的差异。虽然腹泻在该国不同地区的相对重要性似乎存在相当明显的差异,而且腹泻病不像世界其他一些地区那样是一场大灾难,但它仍然是人们前往医疗机构就诊的主要原因,是该国许多医院第二或第三常见的入院原因,也是一个重要且往往可预防的死亡原因。对腹泻病因的有限研究表明,轮状病毒、志贺氏菌以及致病性和产毒性大肠杆菌非常重要。儿童腹泻病的控制不仅基于早期和适当的治疗,还基于预防策略。这些策略包括母乳喂养(拯救了成千上万巴布亚新几内亚儿童的生命,而现在再次受到威胁),通过良好的营养、免疫接种和儿童疾病的早期治疗确保良好的宿主防御能力,以及确保令人满意的环境卫生和个人卫生。增加液体摄入量以预防脱水仍然是急性腹泻病早期管理的最重要部分。在治疗脱水儿童时,联合国儿童基金会基于葡萄糖的口服补液疗法广泛可得,但使用情况并不理想。基于谷物的口服补液溶液有显著优势,应鼓励使用当地制备的此类溶液。腹泻期间应继续母乳喂养,除非有乳糖不耐受的特殊禁忌。在任何情况下,腹泻期间都应维持并尽可能增加儿童的营养摄入。在治疗腹泻儿童时使用抗生素有特定指征。没有这些指征时使用抗生素不仅没有必要,而且可能有害。持续性腹泻(持续超过14天)与高死亡率和严重营养不良相关。因此,对于腹泻持续超过7天的儿童,按照标准指南进行适当管理非常重要。