Gebbers J O, Otto H F
Virchows Arch A Pathol Anat Histol. 1977 Jul 11;374(4):271-3. doi: 10.1007/BF00432650.
Inflammatory cell infiltrates in ulcerative colitis have been investigated by means of the immunoperoxidase method and by electronmicroscopy. Considerable morphological and functional changes of the local plasma cell population have been found. The absolute number of plasma cells is raised with a marked increase of IgG-cells and a relative decrease of IgA-cells. In particular complement (C3) has been demonstrated at the basement membrane of the surface epithelium and between epithelial cells. The significance of these findings, as a local humoral immune response, is briefly considered, with regard to their possible pathogenetic importance in aggravating and perpetuating the disease.
通过免疫过氧化物酶法和电子显微镜对溃疡性结肠炎中的炎性细胞浸润进行了研究。发现局部浆细胞群体有相当大的形态和功能变化。浆细胞的绝对数量增加，IgG细胞显著增多，IgA细胞相对减少。特别是在表面上皮的基底膜和上皮细胞之间已证实有补体（C3）。简要考虑了这些发现作为局部体液免疫反应的意义，以及它们在加重和延续疾病方面可能的致病重要性。
