Novikova A V, Shcherbakov I T, Ol'shanskiĭ Ia O, Iurkov M M, Levitan M Kh
Arkh Patol. 1982;44(9):31-9.
Histological, morphometric, and immunohistochemical studies (with detection of the local production of IgA, IgM, IgG, IgE, and IgD, secretory component of IgA, and deposition of the third complement component, C3) were carried out on biopsies of the colon mucosa from 66 patients with recurrent and continuous forms of nonspecific ulcerative colitis and 16 patients with Crohn's disease. Inflammation in the colon mucosa in the diseases under study was found to be accompanied by marked activation of the local immune system, increased local production of IgA and IgM as well as IgG, particularly in those parts of the mucosa which had no glands. Local synthesis of IgE and IgD also increases indicating allergic reaction in the mucosa alongside with tissue eosinophilia. The basal membrane of the surface epithelium was found to have C3 depositions. A typical feature was the lack of correlation between infiltration of the layer proper of the mucosa and epithelium which is regarded to be a manifestation of deficiency of T-lymphocytes (subpopulation of suppressors or lymphocytes taking part in regulation of epithelium regeneration).
对66例复发型和持续型非特异性溃疡性结肠炎患者以及16例克罗恩病患者的结肠黏膜活检组织进行了组织学、形态计量学和免疫组织化学研究（检测局部产生的IgA、IgM、IgG、IgE和IgD、IgA的分泌成分以及第三补体成分C3的沉积）。研究发现，所研究疾病的结肠黏膜炎症伴有局部免疫系统的显著激活，局部IgA、IgM以及IgG产生增加，尤其是在无腺体的黏膜部位。IgE和IgD的局部合成也增加，表明黏膜存在过敏反应并伴有组织嗜酸性粒细胞增多。发现表面上皮的基底膜有C3沉积。一个典型特征是黏膜固有层和上皮的浸润之间缺乏相关性，这被认为是T淋巴细胞（抑制细胞亚群或参与上皮再生调节的淋巴细胞）缺乏的表现。
