Cavaillon J M, Munoz C, Fitting C, Misset B, Carlet J
Unité d'Immuno-Allergie, Institut Pasteur, Paris, France.
Circ Shock. 1992 Oct;38(2):145-52.
Circulating cytokines, particularly TNF alpha, IL-1, IL-6 and IL-8, can be detected during severe infections consecutively to an exacerbate release by activated cells. The presence or absence of cytokines within biological fluids reflects a rather complex balance between enhancing and inhibitory signals acting on producer cells, between production and catabolism, and between their binding to the target cells and the modulation of their receptors on the cell surface. Furthermore, their presence does not necessarily parallel their activity and a possible interplay between the cytokines and their corresponding inhibitors should be considered. On the contrary, the absence of detectable circulating cytokines does not indicate an absence of production by activated cells. We discuss the concept that circulating cytokines represent the tip of the iceberg.
在严重感染期间，循环细胞因子，尤其是肿瘤坏死因子α、白细胞介素-1、白细胞介素-6和白细胞介素-8，可在活化细胞加剧释放后被连续检测到。生物体液中细胞因子的存在与否反映了作用于产生细胞的增强和抑制信号之间、产生和分解代谢之间、它们与靶细胞的结合以及细胞表面受体的调节之间相当复杂的平衡。此外，它们的存在不一定与其活性平行，应考虑细胞因子与其相应抑制剂之间可能的相互作用。相反，未检测到循环细胞因子并不表明活化细胞不产生。我们讨论了循环细胞因子代表冰山一角这一概念。
